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February 2018

“My lab is using a process very similar to iPS derivation. The only difference is that we perform reprogramming for a very short period of time and in a very controlled fashion. By doing so we are discovering that we can erase or revert a great deal of cellular aging while leaving the function of a cell unaltered. We have also discovered that, unlike the iPS derivation, our rejuvenation process is very efficient and can engage a large number of cells, making us hope that one day we may find a way to apply it to all the cells of the body.”

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February 2018

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“The potential applications could be dramatic, but that doesn’t mean that we are going to become immortal in some problematic way. After all, one way or the other, we have to die. We will just understand aging in a better way, and develop better drugs, and keep people happier and healthier for a few more years.”

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January 2017

“What we have learnt from Somatic Cell Nuclear Transfer and induced Pluripotent Stem Cells technologies indicates that reprogramming of somatic cells to an embryonic-like state affects not only the “function” of the cells but also their age.”

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November 2016

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“A promising therapeutic strategy for diverse genetic disorders involves transplantation of autologous stem cells that have been genetically corrected ex vivo.”

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February 2016

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The technology of reprogramming differentiated cells into a pluripotent state, which can be used to derive virtually any cell type in vitro, has ignited the field of regenerative medicine. An equally revolutionary, but yet to be harnessed phenomenon, is the reset of age that occurs en route to pluripotency. This rejuvenation is clearly evident during reproduction, resulting in a young offspring from aged parental cells. Artificial reprogramming techniques built off this process, such as somatic cell nuclear transfer (SCNT) and induced pluripotent stem cell (iPSC) reprogramming techniques, are showing growing evidence for rejuvenation at the cellular level. These findings all points to an intimate relationship between reprogramming to pluripotency and the reset of age, and iPSC technology, especially, offers the possibility of a man‐made intervention in the aging process. Though in vitro cell reprogramming has been studied arguably for the last three decades, this application of specifically developing a protocol to rejuvenate cells, tissues, even whole organs has only just begun to be explored. There are still many challenges to realization but this technology has already famously shown that cell differentiation is more than a one‐way street, and, maybe, so is aging.”

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